The objective of the present work is to investigate the wound healing activity of bark methanolic extract of Coccinea grandis in rats by simultaneous estimation of the essential biochemical parameters such as protein, DNA, uric acid and hexosamine levels along with excision wound model. The effect of the 5 and 10% w/w ointments of methanol extract of Coccinea grandis was evaluated by excision wound model. The study was carried out on four groups of rats containing six in each group. Nitrofurazone 0.2% was used as standard. The parameters like percentage of wound contraction on alternate days and epithelialization period were studied. In order to strengthen the work protein, DNA, uric acid and hexosamine estimations were also carried. Except control group, rest of the groups significantly (P<0.001) promoted the healing process and biochemical parameters in the wound model studied. The wound healing activity was more significant in treated group of animals due to increase in protein, DNA and stable levels of hexosamine and uronic acid.
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